GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9910950 | 1 | rs7216660 | chr17:64147376 | AXIN2 | chr17:63524685-63637183:- | 0.54 | 4.63 | 4.94E-6 | Presence of antiphospholipid antibodies |
| BLCA | cis | rs9303401 | 1 | rs7218362 | chr17:56888299 | RAD51C | chr17:56769963-56811690:+ | 0.29 | 5.15 | 4.09E-7 | Cognitive test performance |
| BLCA | cis | rs7221109 | 1 | rs7221109 | chr17:38770286 | KRT24 | chr17:38854244-38860002:- | 0.3 | 5.62 | 3.61E-8 | Type 1 diabetes |
| BLCA | cis | rs9894429 | 1 | rs7222241 | chr17:79574714 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs9914544 | 1 | rs7223231 | chr17:18811846 | FAM18B | chr17:18684582-18710026:+ | -0.23 | -4.23 | 2.92E-5 | Educational attainment (years of education) |
| BLCA | cis | rs9894429 | 1 | rs7223613 | chr17:79574803 | TSPAN10 | chr17:79609349-79615778:+ | -0.49 | -8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs9902453 | 1 | rs7223786 | chr17:28332107 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -3.94 | 9.84E-5 | Coffee consumption (cups per day) |
| BLCA | cis | rs732528 | 1 | rs7238284 | chr18:48373876 | MRO | chr18:48321491-48351754:- | 0.23 | 4.15 | 4.12E-5 | Entorhinal cortical thickness |
| BLCA | cis | rs7246967 | 1 | rs7246967 | chr19:23056346 | ZNF492 | chr19:22817126-22850472:+ | -0.3 | -4.03 | 6.82E-5 | Bronchopulmonary dysplasia |
| BLCA | cis | rs8102137 | 1 | rs7247779 | chr19:30297919 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 4.08 | 5.38E-5 | Bladder cancer |
| BLCA | cis | rs7258015 | 1 | rs7250300 | chr19:10448660 | QTRT1 | chr19:10812112-10824042:+ | 0.2 | 3.84 | 0.000146 | Systemic lupus erythematosus or rheumatoid arthritis |
| BLCA | cis | rs7258015 | 1 | rs7250300 | chr19:10448660 | YIPF2 | chr19:11033446-11039357:- | 0.27 | 4.22 | 3.1E-5 | Systemic lupus erythematosus or rheumatoid arthritis |
| BLCA | cis | rs4808801 | 1 | rs7252707 | chr19:18612257 | LRRC25 | chr19:18501955-18508421:- | -0.1 | -3.84 | 0.000141 | Breast cancer |
| BLCA | cis | rs9876781 | 1 | rs725310 | chr3:48418571 | TREX1 | chr3:48501186-48509043:+ | 0.19 | 3.96 | 9.04E-5 | Longevity |
| BLCA | cis | rs7258015 | 1 | rs7254041 | chr19:10448636 | YIPF2 | chr19:11033446-11039357:- | 0.25 | 3.97 | 8.51E-5 | Systemic lupus erythematosus or rheumatoid arthritis |